Orlistat 60 mg OTC (Leanora) — How It Works, Side Effects, FAQs (Sept 2025)

Name: Leanora (Orlistat 60 mg, OTC)
Brand: Leanora
SKU: LEANORA-60MG-60CT
Price: 39.99 USD
Availability: InStock

Manufacturing
Produced in facilities operating under cGMP guidelines. Lot-level testing performed prior to release.

Transparency
Drug Facts available. Certificates of Analysis (CoA) will be posted here for direct download.

Support
Email responses typically within 1–2 business days.

How orlistat 60 mg works

Mechanism: Orlistat reversibly inhibits gastric and pancreatic lipases—enzymes that hydrolyze triglycerides into absorbable free fatty acids and monoglycerides. By interrupting this step, ~25–30% of ingested fat is not absorbed and is instead excreted.

What to expect: When used with a reduced-calorie, low-fat diet and regular activity, programs show modest but meaningful weight loss over time. Consistency with meal planning is key.

Area	Effect
Stomach & small intestine	Inhibits GI lipases that break down dietary triglycerides
Calories from fat	~25–30% remain unabsorbed per fat-containing meal
Best paired with	Reduced-calorie, low-fat pattern to support results & minimize GI effects

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Feature	Orlistat 60 mg (OTC)	Rx GLP-1s	OTC stimulants
Mechanism	Reduces fat absorption in the gut	Appetite/GLP-1 pathway	Stimulant-based appetite effects
Access	Over-the-counter	Prescription only	Over-the-counter
Use	With meals	Mostly injections	Tablets/capsules

General information only; consult a clinician for individualized guidance.

Safety at a glance

GI effects (e.g., loose/oily stools, urgency) may occur—especially with high-fat meals; these often lessen with diet adjustments.
Do not use if you have chronic malabsorption or cholestasis. Discuss medicines that may interact with your healthcare professional.
If you’re pregnant, breastfeeding, or have underlying conditions, ask a clinician before use.

What’s inside

Active: Orlistat 60 mg (OTC strength).

Inactive: See Drug Facts label.

Download Drug Facts (PDF)

Regulatory status

Ingredient approval: Orlistat 60 mg is an FDA-approved OTC drug ingredient when marketed in compliance with FDA regulations and labeling requirements.
NDC & listing: A marketed OTC drug should display a valid NDC on the packaging and appear in the FDA NDC Directory. Current NDC: Pending — we will publish it with direct FDA links once assigned.
Documentation: CoAs will be posted for each lot. Manufacturing under cGMP in FDA-registered facilities.

FAQ

Is Leanora the same as prescription orlistat?

No. Prescription strength is higher. Use OTC products only as directed on their labels.

How much fat does orlistat block per meal?

Approximately 25–30% of ingested dietary fat is prevented from being absorbed when taken with a fat-containing meal.

What side effects should I expect with orlistat 60 mg?

Most effects are gastrointestinal (e.g., loose/oily stools), especially with higher-fat meals. These often lessen with diet adjustments.

Do I need a multivitamin while taking orlistat?

Because fat absorption is reduced, a multivitamin containing A, D, E, and K is commonly recommended. Take it at a different time from orlistat.

How can I verify if a brand is FDA-listed?

Look for an NDC on the package and confirm the listing in the FDA NDC Directory.